Not all gifted children have Autism, and not all children with Autism are gifted. Clinicians often over-rely on classifying observations of gifted children’s behaviors to diagnose Autism. Such a process not only results in many gifted children being misdiagnosed with Autism, but it also does not provide detailed information about how to approach the treatment of gifted children who do in fact have Autism. The diagnostic process requires a more robust clinical assessment based in the principles of neuropsychology. Taking a deeper dive into a gifted child’s neuropsychological functioning not only aids in more reliably ruling out Autism, but it also empowers parents in helping their twice-exceptional children find greater success in life.